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  • Title: A controlled-release nanocarrier with extracellular pH value driven tumor targeting and translocation for drug delivery.
    Author: Zhao Z, Meng H, Wang N, Donovan MJ, Fu T, You M, Chen Z, Zhang X, Tan W.
    Journal: Angew Chem Int Ed Engl; 2013 Jul 15; 52(29):7487-91. PubMed ID: 23757374.
    Abstract:
    This pHLIP is no flop: Functionalizing mesoporous silica nanoparticles (MSNs) with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment. At low pH values, pHLIPss inserts into the cell membrane and translocates carriers into cells, where the cargo is released by the cleavage of the pHLIPss disulfide bonds (see scheme).
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