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  • Title: Arrestins: role in the desensitization, sequestration, and vesicular trafficking of G protein-coupled receptors.
    Author: Walther C, Ferguson SS.
    Journal: Prog Mol Biol Transl Sci; 2013; 118():93-113. PubMed ID: 23764051.
    Abstract:
    Over the years, β-arrestins have emerged as multifunctional molecular scaffolding proteins regulating almost every imaginable G protein-coupled receptor (GPCR) function. Originally discovered as GPCR-desensitizing molecules, they have been shown to also serve as important regulators of GPCR signaling, sequestration, and vesicular trafficking. This broad functional role implicates β-arrestins as key regulatory proteins for cellular function. Hence, this chapter summarizes the current understanding of the β-arrestin family's unique ability to control the kinetics as well as the extent of GPCR activity at the level of desensitization, sequestration, and subsequent intracellular trafficking.
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