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  • Title: Is a booster dose necessary in children after immunization with live attenuated Japanese encephalitis vaccine?
    Author: Choi UY, Lee SY, Kim KH, Kim DS, Choi KM, Cha SH, Kang JH.
    Journal: J Trop Pediatr; 2013 Oct; 59(5):423-5. PubMed ID: 23764540.
    Abstract:
    Japanese encephalitis virus is a common cause of encephalitis in Asian children; therefore, maintenance of immunity against Japanese encephalitis virus is essential. Although many countries recommend booster vaccination, some trials have concluded that administration of one or two vaccinations is sufficient. The current study was conducted to evaluate immunogenicity and safety after a booster vaccination with live attenuated vaccine. For 68 study subjects, measurement of antibody titer was performed before and at 4-6 weeks after administration of a booster dose. Adverse reactions occurring at the injection site and systemic adverse reactions were documented. The percentages of subjects with seroprotective neutralizing antibody titers was 100% before and after booster vaccination, and the geometric mean titer increased after booster vaccination. Thus, we predict that immunity will be maintained for a long time by an amnestic response. Low percentages of adverse reactions indicated the safety of the immunizations.
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