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  • Title: Antibody kinetics in serological indication of chronic Q fever: the Greek experience.
    Author: Kokkini S, Chochlakis D, Vranakis I, Angelakis E, Tselentis Y, Gikas A, Psaroulaki A.
    Journal: Int J Infect Dis; 2013 Nov; 17(11):e977-80. PubMed ID: 23773241.
    Abstract:
    BACKGROUND: Q fever caused by the pathogen Coxiella burnetii may have both acute and chronic manifestations. Although paired sera are not required for the diagnosis of chronic Q fever, monitoring of antibody titers can be used to examine the course of treatment. Monitoring both phase II and phase I antibodies may be of limited diagnostic value, but it is a useful means of determining the response to treatment and possible disease relapses. METHODS: In the current survey we determined IgG and IgM of both phase I and phase II for 35 patients suffering from chronic Q fever in an attempt to draw conclusions on the kinetics of the antibodies throughout the course of the disease. RESULTS: Overall, 33 cases were included in the study. Of the 33 patients, 32 had a good outcome. CONCLUSIONS: Our findings support the general belief that a long period of serological monitoring is required for patients with chronic Q fever.
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