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  • Title: Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.
    Author: Horrocks P, Pickard MR, Parekh HH, Patel SP, Pathak RB.
    Journal: Org Biomol Chem; 2013 Aug 07; 11(29):4891-8. PubMed ID: 23779132.
    Abstract:
    3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an interesting activity against the tested strain of Mycobacterium tuberculosis H37Rv. The results suggest that 1,3,4-oxadiazoles and 5-pyrazolinones bearing a core pyrazole scaffold may be promising antifungal and antitubercular agents.
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