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  • Title: Catalytic enantioselective difluoroalkylation of aldehydes.
    Author: Zhang P, Wolf C.
    Journal: Angew Chem Int Ed Engl; 2013 Jul 22; 52(30):7869-73. PubMed ID: 23780866.
    Abstract:
    Copper-catalyzed bond scission of pentafluorobutane-1,3-diones generates difluoroenolates that react with aldehydes to give a wide range of chiral α,α-difluoro-β-hydroxy ketones within a few hours in up to 99 % yield and 92 % ee. The synthetic utility of this reaction is demonstrated with the stereoselective synthesis of a chiral anti-1,3-diol exhibiting a central difluoromethylene unit and efficient conversion to a 2,2-difluoro-3-hydroxy carboxylic acid.
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