These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Prognostic impact of lymphatic invasion of colorectal cancer: a single-center analysis of 1,616 patients over 24 years.
    Author: Akagi Y, Adachi Y, Ohchi T, Kinugasa T, Shirouzu K.
    Journal: Anticancer Res; 2013 Jul; 33(7):2965-70. PubMed ID: 23780987.
    Abstract:
    BACKGROUND: The degree of lymph node metastasis represents an important prognostic factor for cancer. Lymphovascular invasion is a traditional tool for estimating the aggressiveness of colorectal cancer. AIM: To determine correlations between lymphatic invasion and lymph node metastasis or disease stage, and clarify the prognostic impact of lymphatic invasion. PATIENTS AND METHODS: Patients (N=1,616) who underwent curative resection of primary colorectal adenocarcinoma at the Kurume University Hospital were included. Lymphatic invasion was calculated as an average and the degree was also determined (Ly0-3). Clinicopathological factors including lymphatic invasion were assessed by uni- and multivariate analyses to determine factors affecting survival. Survival was compared between different degrees of lymphatic invasion and lymph node metastasis. RESULTS: Lymphatic invasion was absent (Ly0) in 806 patients (50%), and lymph node metastasis was absent (N0) in 1,085 patients (67%). Ninety-one percent of N0 patients were Ly0-1, 72% of N1 were Ly0-1, and 54% of N2 were Ly2-3. All patients with stage 0 disease (100%) were Ly0, 95% of stage I were Ly0-1, 46% of stage II were Ly1-2, and 36% of stage III were Ly2-3. Five- and 10-year survival rates were 83% and 68% in Ly0, 73% and 56% in Ly1, 66% and 49% in Ly2, 63% and 48% in Ly3, 81% and 67% in N0, 69% and 57% in N1, and 60% and 52% in N2, respectively (p<0.0001 each). CONCLUSION: Lymphatic invasion in colorectal cancer correlates well with the status of lymph node metastasis and disease stage, representing an independent prognostic factor after curative resection. Lymphatic invasion can be used for evaluating tumor aggressiveness and estimating patient survival, irrespective of the actual number of positive lymph nodes found.
    [Abstract] [Full Text] [Related] [New Search]