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  • Title: Microdissection of the fragile X region.
    Author: MacKinnon RN, Hirst MC, Bell MV, Watson JE, Claussen U, Ludecke HJ, Senger G, Horsthemke B, Davies KE.
    Journal: Am J Hum Genet; 1990 Aug; 47(2):181-6. PubMed ID: 2378345.
    Abstract:
    We have microdissected and cloned the region around the fragile site at Xq27.3 on the human X chromosome. All of the clones tested map to the Xq27-Xq28 region, and detailed mapping on a panel of somatic cell hybrids indicates that the microdissected library contains sequences derived from both sides of the fragile X mutation. Some of these clones give signals in rodent DNA. This library demonstrates the power of microdissection for the identification of potential coding sequences near a disease locus and provides a promising resource for the identification of the fragile X mutation.
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