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  • Title: Influence of TSPO genotype on 11C-PBR28 standardized uptake values.
    Author: Yoder KK, Nho K, Risacher SL, Kim S, Shen L, Saykin AJ.
    Journal: J Nucl Med; 2013 Aug; 54(8):1320-2. PubMed ID: 23785173.
    Abstract:
    UNLABELLED: (11)C-PBR28 binds to the high-affinity state of the translocator protein 18 kDa (TSPO). A single-nucleotide polymorphism (rs6971) within the human TSPO gene determines the affinity state of the TSPO. The rs6971 genotype determines whether individuals express the high-, low-, or mixed-affinity phenotype of TSPO. The rs6971 genotype corresponds to in vivo (11)C-PBR28 binding, as measured quantitatively by total volume of distribution. However, it is not known whether standardized uptake value (SUV) can detect differences in brain (11)C-PBR28 uptake by TSPO genotype. METHODS: Thirty-two older adults (71.8 ± 7.94 y old) underwent (11)C-PBR28 PET scanning; rs6971 genotype was imputed after genomewide genotyping. SUV was extracted for several brain regions. The sample included 19 C/C carriers (high-affinity phenotype), 12 T/C carriers (mixed-affinity), and 1 T/T carrier (low-affinity) for rs6971. RESULTS: SUV was 30% lower in T/C subjects than in C/C subjects. CONCLUSION: The results indicate that brain (11)C-PBR28 SUV is sensitive to TSPO genotype.
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