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  • Title: Treatment response of airway clearance assessed by single-breath washout in children with cystic fibrosis.
    Author: Abbas C, Singer F, Yammine S, Casaulta C, Latzin P.
    Journal: J Cyst Fibros; 2013 Dec; 12(6):567-74. PubMed ID: 23790270.
    Abstract:
    BACKGROUND: We studied the ability of 4 single-breath gas washout (SBW) tests to measure immediate effects of airway clearance in children with CF. METHODS: 25 children aged 4-16 years with CF performed pulmonary function tests to assess short-term variability at baseline and response to routine airway clearance. Tidal helium and sulfur hexafluoride (double-tracer gas: DTG) SBW, tidal capnography, tidal and vital capacity nitrogen (N2) SBW and spirometry were applied. We analyzed the gasses' phase III slope (SnIII--normalized for tidal volume) and FEV1 from spirometry. RESULTS: SnIII from tidal DTG-SBW, SnIII from vital capacity N2-SBW, and FEV1 improved significantly after airway clearance. From these tests, individual change of SnIII from tidal DTG-SBW and FEV1 exceeded short-term variability in 10 and 6 children. CONCLUSIONS: With the tidal DTG-SBW, an easy and promising test for peripheral gas mixing efficiency, immediate pulmonary function response to airway clearance can be assessed in CF children.
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