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  • Title: Sensitivity of male reproductive endpoints in nonhuman primate toxicity studies: a statistical power analysis.
    Author: Cappon GD, Potter D, Hurtt ME, Weinbauer GF, Luetjens CM, Bowman CJ.
    Journal: Reprod Toxicol; 2013 Nov; 41():67-72. PubMed ID: 23792114.
    Abstract:
    To determine the sensitivity of male reproductive toxicity endpoints in NHPs we performed a power analysis of routine and triggered endpoints using control data from sexually mature Asian and Mauritian NHPs. The power to detect a 50% change from control was 13-30% for male reproductive organ weights, ∼30% for testicular volume, 6-66% for seminal analyses and 10-78% for male hormones. Overall, male reproductive endpoints have poor power (less than 80%) to detect a 50% change from control with a group size of 3 monkeys. Confidently identifying adverse male reproductive effects with these endpoints would likely require specialized study designs with larger group sizes. Triggering of non-routine endpoints in cases where there is special concern for male reproductive toxicity is unlikely to increase sensitivity to detect adverse effects.
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