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  • Title: The SaeR/S two-component system induces interferon-gamma production in neutrophils during invasive Staphylococcus aureus infection.
    Author: Watkins RL, Zurek OW, Pallister KB, Voyich JM.
    Journal: Microbes Infect; 2013; 15(10-11):749-54. PubMed ID: 23792139.
    Abstract:
    Invasive Staphylococcus aureus (S. aureus) disease is associated with neutrophil activity and pro-inflammatory cytokine expression, including interferon-gamma (IFNγ). Using a mouse model of S. aureus peritonitis, we identify neutrophils as the predominant source of IFNγ and link this induction with the SaeR/S two-component gene regulatory system. Relative to wild-type (BALB/c) mice, IFNγ-deficient mice demonstrated increased bacterial clearance and reduced cellular cytotoxicity following intraperitoneal challenge with S. aureus. Interestingly, bacterial burden and cytotoxicity were similar in BALB/c and IFNγ-deficient mice when infected with an isogenic saeR/S mutant strain. These findings suggest saeR/S-mediated neutrophil-derived IFNγ diminishes innate antibacterial mechanisms against S. aureus.
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