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Title: The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. Author: Sak ME, Soydinc HE, Sak S, Evsen MS, Alabalik U, Akdemir F, Gul T. Journal: Int J Surg; 2013; 11(9):967-70. PubMed ID: 23796447. Abstract: BACKGROUND: To evaluate the protective effects of curcumin in experimental ischemia and ischemia/reperfusion (I/R) injury of rat ovaries. METHODS: Forty-eight female adult Wistar Albino rats were used. Rats divided into six groups and designed: Sham, Torsion, Detorsion, Sham + Curcumin, Torsion + Curcumin, and Detorsion + Curcumin. Except for the Sham and Sham + Curcumin group, all groups were performed to bilateral adnexal torsion for 3 h. Bilateral adnexal detorsion was implemented in the Detorsion and Detorsion + Curcumin groups. The injection of curcumin was intraperitoneally achieved 30 min before the sham, torsion and detorsion. RESULTS: Total oxidant status levels (TOS), oxidative stress index (OSI) and histologic scores values of ovarian tissue were higher in the torsion and detorsion groups than the sham group (p < 0.05). There was a strong correlation between the total histologic scores of I/R injury and the OSI (r = 0.809, p < 0.001). By the use of curcumin, a significant decrease was established in the mean levels of oxidant markers and histopathologic scores of the ovarian tissues. CONCLUSIONS: Administration of curcumin is effective in reversing tissue damage induced by ischemia-reperfusion injury in ovarian torsion.[Abstract] [Full Text] [Related] [New Search]