These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Human necrotizing vasculitis: immunoglobulins and complement in vessel walls of cutaneous lesions and normal skin.
    Author: Sams WM, Claman HN, Kohler PF, McIntosh RM, Small P, Mass MF.
    Journal: J Invest Dermatol; 1975 Jun; 64(6):441-5. PubMed ID: 237967.
    Abstract:
    Immunoglobulins and C3 were detected by immunofluorescence in the blood vessel walls of biopsies of clinically normal skin in patients with active necrotizing vasculitis. Of the 13 patients studied, 9 had C3 and 6 of these had IgM or IgA in biopsies of lesions of vasculitis. In adjacent clinically normal skin, 7 patients had C3 and 3 of these also had IgM or IgA. These findings support the hypothesis that immunoglobulins and complement are present in vessels of some patients prior to chemotaxis of polymorphonuclear leukocytes and the resulting inflammatory purpuric lesions so characteristic of necrotizing vasculitis.
    [Abstract] [Full Text] [Related] [New Search]