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  • Title: Primary sclerosing cholangitis and cholangiocarcinoma: pathogenesis and modes of diagnostics.
    Author: Ehlken H, Schramm C.
    Journal: Dig Dis; 2013; 31(1):118-25. PubMed ID: 23797133.
    Abstract:
    Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammation of the intra- and extrahepatic bile duct system. PSC patients have an increased risk to develop hepatobiliary as well as extrahepatic malignancies. The goal of a surveillance strategy for hepatobiliary malignancy in these patients is the detection of early cancer which will allow a potentially curative therapy. Here, we focus on a conceptual review of the pathogenesis of cholangiocellular carcinoma and gallbladder cancer and we will discuss a rational approach for the surveillance of these malignancies in PSC patients.
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