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  • Title: Caesalpins A-H, bioactive cassane-type diterpenes from the seeds of Caesalpinia minax.
    Author: Ma G, Yuan J, Wu H, Cao L, Zhang X, Xu L, Wei H, Wu L, Zheng Q, Li L, Zhang L, Yang J, Xu X.
    Journal: J Nat Prod; 2013 Jun 28; 76(6):1025-31. PubMed ID: 23806110.
    Abstract:
    Eight new cassane-type diterpenes, caesalpins A-H (1-8), were isolated from the ethyl acetate extract of Caesalpinia minax. Compound 1 displayed significant antiproliferative activity against HepG-2 (IC50 4.7 μM) and MCF-7 (IC50 2.1 μM) cells, and compounds 2 and 4 exhibited selective cytotoxic activities against MCF-7 (IC50 7.9 μM) and AGS (IC50 6.5 μM) cells.
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