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  • Title: Polymyxin derivatives: a patent evaluation (WO2012168820).
    Author: Wu H, Teng P, Niu Y, Li Q, Cai J.
    Journal: Expert Opin Ther Pat; 2013 Aug; 23(8):1075-81. PubMed ID: 23806121.
    Abstract:
    The patent application WO201268820 claims a new class of polymyxin derivatives with potent antibacterial activity, especially toward Gram-negative pathogens. Compared to parent polymyxin B (PMB), the new derivatives have more potent antibacterial activity, as well as reduced cytotoxicity against human renal cells.
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