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  • Title: Glucagon-like peptide-1 (7-36)-NH2: a physiological inhibitor of gastric acid secretion in man.
    Author: O'Halloran DJ, Nikou GC, Kreymann B, Ghatei MA, Bloom SR.
    Journal: J Endocrinol; 1990 Jul; 126(1):169-73. PubMed ID: 2380653.
    Abstract:
    Glucagon-like peptide (GLP)-1 (7-36)-NH2 is a peptide found in the mucosal endocrine cells of the intestine, and plasma levels of GLP-1 (7-36)-NH2 immunoreactivity show a rise after the ingestion of a fat or mixed-component meal. We investigated the effects of physiological infusion of GLP-1 (7-36)-NH2 on a submaximal gastric acid secretion in healthy volunteers at a rate known to mimic the observed postprandial rise in plasma concentrations. Corrected gastric acid output decreased to less than 50% and volume output to 33% of stimulated values. After the infusion, the secretion of gastric acid recovered immediately to preinhibition values. These results suggest a novel role for GLP-1 (7-36)-NH2 as a physiological inhibitor of gastric acid secretion in man.
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