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  • Title: Interchangeability between 24-hour collection and single spot urines for vanillylmandelic and homovanillic acid levels in the diagnosis of neuroblastoma.
    Author: Cangemi G, Barco S, Reggiardo G, Viscardi E, Di Cataldo A, Garaventa A, Melioli G, Conte M.
    Journal: Pediatr Blood Cancer; 2013 Dec; 60(12):E170-2. PubMed ID: 23813598.
    Abstract:
    The determination of the two urinary catecholamine metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) is of crucial importance for the diagnosis and follow-up of neuroblastoma (NB). The standard practice for their measurement requires the use of 24-hour collections that are time consuming and difficult to obtain. In this article, we directly demonstrate that 24-hour collections and single spot urines are interchangeable for the determination of HVA and VMA expressed as ratio on creatinine concentration. This study can be useful for a faster management of NB at onset.
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