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  • Title: The influence of imipramine on dopamine-induced ganglionic inhibition and neurogenic vasodilatation in the dog.
    Author: Willems JL, Bogaert MG.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1975; 286(4):429-36. PubMed ID: 238140.
    Abstract:
    Imipramine potentiates the dopamine-induced inhibition in the paravertebral lumbar ganglia of the dog. Potentiation by imipramine of the dopamine-induced neurogenic vasodilatation in the isolated perfused gracilis muscle, is seen in cross-circulation preparations only, where imipramine is injected into the perfusion circuit of an isolated perfused gracilis muscle, it antagonizes the dopamine-induced neurogenic vasodilatation. When imipramine is injected intravenously into a dog with an autoperfused gracilis muscle, the peripheral antagonism masks the potentiating effect at the ganglionic level, and the dopamine-induced neurogenic vasodilatation is abolished.
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