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  • Title: [The effect of Enzaprost-F (PGF2) cervical tablets on the corpus luteum in the human body].
    Author: Farkas M, Vörös Z.
    Journal: Morphol Igazsagugyi Orv Sz; 1990 Apr; 30(2):134-9. PubMed ID: 2381432.
    Abstract:
    Authors removed dextro-ovary of a patient having 7-9th week of gestation for ovarian cyst during abortion. Preoperative cervical dilation was performed by Enzaprost-F cervical tablet containing 20 mg PGF2 agent. Before and 2, 4 and 6 hours after treatment, serum-progesterone and 17-beta-estradiol level was determined. Drug cervical dilation enabled instrumental termination of pregnancy within 4 hours. Histological finding of yellow body showed initial signs of colloid-cystic degeneration, which was followed by minimal decrease of values of serum-steroid concentrations. Authors presume that change in histological picture of yellow body was caused by effect of cervical tablet containing PGF2 agent. The objective was to ascertain whether a pill containing PGF2alpha was of endocrinological consequence in humans, or possible its luteolytic effect had an anatomical substrate. The progesterone production of corpus luteum was significantly reduced by 20 mg of PGF2alpha placed in the cervix of primigravidas in 7-8 weeks of pregnancy possible indicative of the site of the anatomical substrate of PGF2alpha action. Case 1: Adjacent to the uterus of a tertigravida aged 25 at 7-8 weeks of gestation was a mobile, flexible, smooth, and not sensitive formation the size of a goose egg. Case 2: a secundigravida of aged 29 at 8-9 weeks of pregnancy. In front of the uterus of was a smooth-surfaced, flexible, mobile, not sensitive formation. Following evacuation of the uterus, laparotomy was performed in both cases after insertion of an Enzaprost-F pill (20 mg of PGF2alpha) into the cervix. Blood tests were taken prior to and 2, 4, and 6 hours after treatment for the determination of progesterone and 17-beta-estradiol levels by radioimmunoassay. Results of Case 1: an ovarial sac with corpus luteum was found, and the right adnexa was removed. Results of Case 2: also during laparotomy a cyst was detected on the right side with corpus luteum in it. Right adnexectomy was performed. Dilatation of the cervix with 20 mg of PGF2alpha: 8 mm 2 hours after and 13 mm (Hegar 13) 4 1/2 hours after insertion. Serum progesterone level was 34.7 nmol/1 prior to treatment and at 2, 4, and 6 hours afterwards it was 31.9 and 28.9 nmol/1. The respective serum 17-beta-estradiol levels increased from 7.656 nmol/1 to 7.630, 8.074, and 7.896 nmol/1. Histological examination indicated initial signs of a hypertrophic colloid-cystic aberration of the corpus luteum presumably through the influence of PGF2alpha. A lack of significant decrease of serum steroid concentration values also substantiate this supposition.
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