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  • Title: Cytotoxic activity and apoptosis induction by gaillardin.
    Author: Moghadam MH, Naghibi F, Atoofi A, Rezaie MA, Irani M, Mosaddegh M.
    Journal: Z Naturforsch C J Biosci; 2013; 68(3-4):108-12. PubMed ID: 23819305.
    Abstract:
    Cytotoxic activity of gaillardin, a sesquiterpene lactone isolated from Inula oculus-christi L. (Asteraceae), was assessed in the human breast adenocarcinoma cell line MCF-7, human hepatocellular carcinoma cell line HepG-2, human non-small cell lung carcinoma cell line A-549, and human colon adenocarcinoma cell line HT-29, resulting in IC50 values of 6.37, 6.20, 4.76, and 1.81 microg/mL, respectively, in the microculture tetrazolium-formazan MTT assay. In vitro apoptosis-inducing properties of gaillardin were also evaluated in MCF-7 cells with the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) assay. The results suggest gaillardin as a candidate for further studies in cancer therapy
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