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  • Title: Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism is associated with asthma risk: a meta-analysis.
    Author: Nie W, Xue C, Chen J, Xiu Q.
    Journal: Gene; 2013 Oct 10; 528(2):304-8. PubMed ID: 23820082.
    Abstract:
    BACKGROUND: Epidemiological studies have evaluated the association between Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism and asthma, but the results remain inconclusive. The aim of this study was to perform a meta-analysis to investigate a more authentic association between SCGB1A1 +38A/G polymorphism and asthma. METHODS: Published literature from PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random or fixed-effect model according the between-study heterogeneity. RESULTS: A total of 19 case-control studies in 18 articles were included in the meta-analysis, including 3191 cases and 5182 controls. We found that SCGB1A1 +38A/G polymorphism was associated with a significantly increased risk of asthma risk when all studies were pooled in a dominant model (OR=1.29; 95% CI 1.08-1.54; P=0.005). The cumulative meta-analysis and sensitivity analysis further strengthened the stability of the result. Furthermore, publication bias was not detected. CONCLUSIONS: This study suggested that SCGB1A1 +38A/G polymorphism was a risk factor for asthma. Further large and well-designed studies are needed to confirm this association.
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