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  • Title: Phenanthrenes, 9,10-dihydrophenanthrenes, bibenzyls with their derivatives, and malate or tartrate benzyl ester glucosides from tubers of Cremastra appendiculata.
    Author: Wang Y, Guan SH, Meng YH, Zhang YB, Cheng CR, Shi YY, Feng RH, Zeng F, Wu ZY, Zhang JX, Yang M, Liu X, Li Q, Chen XH, Bi KS, Guo DA.
    Journal: Phytochemistry; 2013 Oct; 94():268-76. PubMed ID: 23820314.
    Abstract:
    Eleven previously unknown compounds and 23 known compounds, including 20 phenanthrene or 9,10-dihydrophenanthrene derivatives, five bibenzyls, seven malate or tartrate benzyl ester glucosides, adenosine and gastrodin were isolated from tubers of Cremastra appendiculata. Among the obtained compounds, two are the first isolated dimers with one phenanthrene or bibenzyl unit connected to C-3 of 2,3,4,5-tetrahydro-phenanthro[2,1-b]furan moiety. In addition, 33 of these compounds were evaluated in vitro for their cytotoxic activity against two cancer cell lines. Among the compounds examined, one compound showed moderate cytotoxic activity, while five showed weak cytotoxic activity against the A549 cell line.
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