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  • Title: Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.
    Author: Gause WC, Wynn TA, Allen JE.
    Journal: Nat Rev Immunol; 2013 Aug; 13(8):607-14. PubMed ID: 23827958.
    Abstract:
    Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.
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