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  • Title: Three dimensional structure of a bacterial α-l-fucosidase with a 5-membered iminocyclitol inhibitor.
    Author: Wright DW, Moreno-Vargas AJ, Carmona AT, Robina I, Davies GJ.
    Journal: Bioorg Med Chem; 2013 Aug 15; 21(16):4751-4. PubMed ID: 23830696.
    Abstract:
    Fucosidases, enzymes that cleave fucose from the non-reducing end of a glycan, represent promising medicinal targets reflecting their roles in cancer metastasis, inflammation, host-parasite interactions and the lysosomal storage disorder fucosidosis. The X-ray crystal structures of Bacteroides thetaiotaomicron GH29 α-l-fucosidase (BtFuc2970) in a new crystal form (at a resolution of 1.59Å) and liganded with a 5-membered iminocyclitol inhibitor (1.73Å) are reported herein. The 5-membered iminocyclitol binds in a (3)E conformation, mimicking the proposed (3)H4 half chair transition-state of the enzyme catalysed reaction, and its Ki for BtFuc2970 was determined as 2μM. Structural analysis of fucosidase inhibition through 5-membered iminocyclitols will aid in the rational design of more potent fucosidase inhibitors for treatment of a range of medical conditions.
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