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  • Title: Assessment of cerebral perfusion in post-traumatic brain injury patients with the use of ICG-bolus tracking method.
    Author: Weigl W, Milej D, Gerega A, Toczylowska B, Kacprzak M, Sawosz P, Botwicz M, Maniewski R, Mayzner-Zawadzka E, Liebert A.
    Journal: Neuroimage; 2014 Jan 15; 85 Pt 1():555-65. PubMed ID: 23831529.
    Abstract:
    The aim of this study was to verify the usefulness of the time-resolved optical method utilizing diffusely reflected photons and fluorescence signals combined with intravenous injection of indocyanine green (ICG) in the assessment of brain perfusion in post-traumatic brain injury patients. The distributions of times of flight (DTOFs) of diffusely reflected photons were acquired together with the distributions of times of arrival (DTAs) of fluorescence photons. The data analysis methodology was based on the observation of delays between the signals of statistical moments (number of photons, mean time of flight and variance) of DTOFs and DTAs related to the inflow of ICG to the extra- and intracerebral tissue compartments. Eleven patients with brain hematoma, 15 patients with brain edema and a group of 9 healthy subjects were included in this study. Statistically significant differences between parameters obtained in healthy subjects and patients with brain hematoma and brain edema were observed. The best optical parameter to differentiate patients and control group was variance of the DTOFs or DTAs. Results of the study suggest that time-resolved optical monitoring of inflow of the ICG seems to be a promising tool for detecting cerebral perfusion insufficiencies in critically ill patients.
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