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  • Title: Structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii.
    Author: Nakamura T, Mori A, Niiyama M, Matsumura H, Tokuyama C, Morita J, Uegaki K, Inoue T.
    Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun; 2013 Jul; 69(Pt 7):719-22. PubMed ID: 23832195.
    Abstract:
    The crystal structure of peroxiredoxin from the anaerobic hyperthermophilic archaeon Pyrococcus horikoshii (PhPrx) was determined at a resolution of 2.25 Å. The overall structure was a ring-type decamer consisting of five homodimers. Citrate, which was included in the crystallization conditions, was bound to the peroxidatic cysteine of the active site, with two O atoms of the carboxyl group mimicking those of the substrate hydrogen peroxide. PhPrx lacked the C-terminal tail that forms a 32-residue extension of the protein in the homologous peroxiredoxin from Aeropyrum pernix (ApPrx).
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