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  • Title: Synthesis and evaluation of the analgesic and antiinflammatory activities of N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes.
    Author: Daidone G, Raffa D, Maggio B, Plescia S, Matera M, Caruso A.
    Journal: Farmaco; 1990 Mar; 45(3):285-92. PubMed ID: 2383344.
    Abstract:
    The analgesic and antiinflammatory activities of some N,N'-bis(2-hydroxybenzoyl)-diaminoalkanes 3 a-l were studied. The compounds were prepared very conveniently by fusion of phenyl salicylate 2 and diaminoalkanes 1 a-l. The pharmacological activities were influenced by the number of carbon atoms in the polimethylenic chain. Some derivatives were more effective and less gastrolesive than salicylamide.
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