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  • Title: [Design, synthesis, and PPARgamma agonistic activity of novel indenone derivatives].
    Author: Qu LL, Ma YH.
    Journal: Yao Xue Xue Bao; 2013 Apr; 48(4):508-13. PubMed ID: 23833937.
    Abstract:
    Agonists of peroxisome proliferator-activated receptor gamma (PPARgamma) are of interest as a treatment of type II diabetes, and indenone derivatives are a new class of non-TZD PPARgamma agonists. Based on existing indenone derivatives, a series of novel ones have been designed and synthesized. Meanwhile the structures have been comfirmed with 1H NMR and MS. Among them, 17b and 19 showed higher agonistic activities than rosiglitazone.
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