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  • Title: [Dyspnoea, cough and B symptoms in a 40-year-old woman].
    Author: Wolfensberger A, Benz R, Russi EW, Tinguely M, Keller C, Gerber B.
    Journal: Internist (Berl); 2013 Aug; 54(8):1011-5. PubMed ID: 23836253.
    Abstract:
    Multicentric Castleman's disease (MCD) is a rare polyclonal lymphoproliferative disorder that is typically accompanied by an overproduction of circulating cytokines (mainly interleukin-6). We here report the case of a 40-year-old HIV-negative woman with pulmonary manifestation of MCD. There is no standard treatment for MCD. In our patient, various treatment courses with immunomodulatory drugs were unsuccessful. Finally, treatment with the interleukin-6 receptor antibody tocilizumab has resulted in continual clinical improvement over the last 5 years.
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