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  • Title: Specific nucleotide changes in the subgenomic promoter region influence infectivity of the sindbis virus.
    Author: Zhu WY, Zhao T, Liang GD.
    Journal: Intervirology; 2013; 56(5):337-42. PubMed ID: 23838061.
    Abstract:
    Transcription of the subgenomic mRNA of Sindbis virus (SINV) is initiated at a subgenomic promoter (SP). Alignment of SINV sequences identified a 68-nucleotide conserved domain spanning -19 to +49 relative to the subgenomic mRNA start site. Nucleotide T or C is present at -18 or +49 in all known SINVs while a Sindbis-like virus XJ-160 has an A or T at a corresponding position. Our results indicate that deletion or substitution of the T at +49 decreased the activity of SP, while substituting T for A at -18 did not decrease the activity of SP or genetic stability of recombinant SINV.
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