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  • Title: Pulsed ultrasound modulated optical tomography utilizing the harmonic response of lock-in detection.
    Author: Ruan H, Mather ML, Morgan SP.
    Journal: Appl Opt; 2013 Jul 01; 52(19):4755-62. PubMed ID: 23842276.
    Abstract:
    Ultrasound modulated optical tomography (USMOT) can image the optical properties of a scattering medium at a spatial resolution approaching that of ultrasound (US). A lock-in parallel speckle detection technique is proposed to detect pulsed US modulated light using a multipixel detector. The frequency components of the pass band match those of the US pulse train and provide efficient detection. The modulation depth is extracted by taking the difference between a pair of speckle patterns modulated by a pair of phase-inversed US bursts. Modification to pulse inversion mode enables the second harmonic US modulation due to nonlinear US propagation to be detected.
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