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  • Title: Hypertension in sickle cell disease.
    Author: Narasimhan C, George T, George JT, Pulimood BM.
    Journal: J Assoc Physicians India; 1990 Jun; 38(6):435-6. PubMed ID: 2384463.
    Abstract:
    We report a young male with sickle cell trait who developed severe hypertension and splenic infarction soon after travel to a high altitude. Hypertension persisted for three days after a diagnostic laparotomy. His blood pressure then continued to be normal over the next one and a half years. Red cell sludging in the small vessels of the kidney possibly activated the renin angiotensin system.
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