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  • Title: Combination of dynamic and integral methods for generating reproducible functional CBF images.
    Author: Lammertsma AA, Cunningham VJ, Deiber MP, Heather JD, Bloomfield PM, Nutt J, Frackowiak RS, Jones T.
    Journal: J Cereb Blood Flow Metab; 1990 Sep; 10(5):675-86. PubMed ID: 2384540.
    Abstract:
    A new method to measure regional CBF is presented, applying both dynamic and integral analyses to a dynamic sequence of positron emission tomographic scans collected during and following the administration of H2(15)O (inhalation of C15O2). The dynamic analysis is used to correct continuously monitored arterial whole-blood activity for delay and dispersion relative to tissue scans. An integral analysis including corrections for this delay and dispersion is then used to calculate CBF on a pixel-by-pixel basis. Normal values and reproducibility over a 2-h period are presented, together with the results of validation and simulation studies. The results indicate that the single-tissue compartment model adequately describes the distribution of H2(15)O in the brain, without recourse to postulating a nonexchanging water pool.
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