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  • Title: Highly sensitive method for the determination of 1-methyl-1,2,3,4-tetrahydro-beta-carboline using combined capillary gas chromatography and negative-ion chemical ionization mass spectrometry.
    Author: Hayashi T, Todoriki H, Iida Y.
    Journal: J Chromatogr; 1990 Jun 08; 528(1):1-8. PubMed ID: 2384547.
    Abstract:
    A sensitive method was developed for the determination of deuterated and non-deuterated 1-methyl-1,2,3,4-tetrahydro-beta-carboline by combined capillary gas chromatography and negative-ion chemical ionization mass spectrometry. 1-Methyl-1,2,3,4-tetrahydro-beta-carboline was converted into a trifluoroacetyl derivative after pretreatment with fluorescamine and extraction with ethyl acetate. The derivative was separated by capillary gas chromatography and determined by selected-ion monitoring. In the determination, [3,3,4,4-2H4]-1-methyl-1,2,3,4-tetrahydro-beta-carboline was used as an internal standard. The method developed in this work was used for the determination of deuterated and non-deuterated 1-methyl-1,2,3,4-tetrahydro-beta-carboline in human urine samples collected before and after administration of [3,3-2H2]-L-tryptophan.
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