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  • Title: Electron-impact ionization detection of scopolamine by gas chromatography-mass spectrometry in rat plasma and brain.
    Author: Deutsch J, Soncrant TT, Greig NH, Rapoport SI.
    Journal: J Chromatogr; 1990 Jun 29; 528(2):325-31. PubMed ID: 2384572.
    Abstract:
    Scopolamine, a muscarinic receptor antagonist, was measured in rat plasma and brain using gas chromatography-mass spectrometry with electron-impact ionization detection. Extracted scopolamine was either directly derivatized or first hydrolyzed to scopine, then derivatized with heptafluorobutyric anhydride, separated on a capillary column and quantified by mass fragmentography. Electron-impact ionization produced a common fragment peak at m/z 138 that was monitored along with trideuterated scopolamine, an internal standard (m/z 141). The method can be used to measure scopolamine concentrations of 2 ng/ml in rat plasma and 20 ng/g in rat brain.
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