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  • Title: Enhanced fecal excretion of bile acids by a new anion-exchange resin possessing a spacer arm in rats.
    Author: Honda Y, Nakano M, Haratake M, Sugii A.
    Journal: J Pharmacobiodyn; 1990 Feb; 13(2):130-5. PubMed ID: 2384849.
    Abstract:
    The effect of a new polystyrene-based, strongly basic, anion-exchange resin possessing an omega-oxobutyl chain as a spacer arm on the fecal bile acid excretion was investigated in rats and compared with that of Dowex 1-X2, chemically equivalent to cholestyramine. The new resin did produce a significant rise in the total fecal bile acid excretion with its ingestion for a period of 4 weeks. Its promoting activity proved to be 2.0- and 1.8-fold more potent than that of Dowex 1-X2 at the 3rd and 4th week, respectively. These results suggest that the introduction of a spacer arm between the polymer backbone and a functional group would lead to an improvement in the in vivo adsorptive efficiency of the resin.
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