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  • Title: A new cytotoxic cembrane diterpene from the roots of Euphorbia pekinensis Rupr.
    Author: Hou P, Zeng Y, Ma B, Bi K, Chen X.
    Journal: Fitoterapia; 2013 Oct; 90():10-3. PubMed ID: 23850541.
    Abstract:
    A new cembrane diterpene, named (-)-(1S)-15-hydroxy-18-carboxycembrene, was isolated from petroleum ether extract of the roots of the Euphorbia pekinensis Rupr. To our knowledge, this compound is the first cembrane-type diterpenoid to be found in the family Euphorbiaceae. The structure was elucidated as (-)-(1S)-15-hydroxy-cembra -2E, 4Z, 7E, 11E-tetraen-18-oic acid by a combination of IR, HR-ESIMS, 1D- and 2D-NMR techniques. (-)-(1S)-15-hydroxy-18-carboxycembrene showed cytotoxic activity against all five human cancer cell lines tested.
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