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  • Title: PDN-21: possible tumor marker for medullary thyroid carcinoma.
    Author: Takami H, Shikata J, Horie H, Sekine K, Ito K.
    Journal: J Surg Oncol; 1990 Aug; 44(4):205-7. PubMed ID: 2385096.
    Abstract:
    The plasma level of PDN-21 was measured by RIA in 10 patients with medullary thyroid carcinoma (MTC). All 10 patients with MTC had extremely elevated PDN-21 levels. The correlations between PDN-21, calcitonin gene-related peptide, and calcitonin, (all of which are calcitonin gene products) were significant (P less than .001) in the 10 MTC patients. This study suggests that PDN-21, as well as calcitonin, may be a useful marker for the detection of patients with MTC.
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