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  • Title: 1,8-Dinitropyrene: comparative mutagenicity in Chinese hamster V79 and CHO cells.
    Author: O'Donovan MR.
    Journal: Mutagenesis; 1990 May; 5(3):275-7. PubMed ID: 2385180.
    Abstract:
    1,8-Dinitropyrene (1,8-DNP) was clearly mutagenic at the hprt locus in CHO cells, but not detectably mutagenic in V79 cells, following a 3-h treatment period. Preliminary data indicate that CHO, but not V79, cells have measurable levels of N-acetyltransferase activity, and this may contribute to the differential sensitivity of the two cell lines to the mutagenicity of 1,8-DNP.
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