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  • Title: Modeling of the cell-electrode interface noise for microelectrode arrays.
    Author: Guo J, Yuan J, Chan M.
    Journal: IEEE Trans Biomed Circuits Syst; 2012 Dec; 6(6):605-13. PubMed ID: 23853261.
    Abstract:
    Microelectrodes are widely used in the physiological recording of cell field potentials. As microelectrode signals are generally in the μV range, characteristics of the cell-electrode interface are important to the recording accuracy. Although the impedance of the microelectrode-solution interface has been well studied and modeled in the past, no effective model has been experimentally verified to estimate the noise of the cell-electrode interface. Also in existing interface models, spectral information is largely disregarded. In this work, we developed a model for estimating the noise of the cell-electrode interface from interface impedances. This model improves over existing noise models by including the cell membrane capacitor and frequency dependent impedances. With low-noise experiment setups, this model is verified by microelectrode array (MEA) experiments with mouse muscle myoblast cells. Experiments show that the noise estimated from this model has <;10% error, which is much less than estimations from existing models. With this model, noise of the cell-electrode interface can be estimated by simply measuring interface impedances. This model also provides insights for micro- electrode design to achieve good recording signal-to-noise ratio.
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