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  • Title: Simulation of shape changes and adhesion phenomena in an elastic model of erythrocytes.
    Author: Leibler S, Maggs AC.
    Journal: Proc Natl Acad Sci U S A; 1990 Aug; 87(16):6433-5. PubMed ID: 2385601.
    Abstract:
    We present simulations of a model of a closed membrane that shares important features with erythrocytes: resistance to bending and shear, membrane asymmetry, and an osmotic pressure difference between the interior and exterior. By varying a few parameters we obtain several realistic (e.g., biconcave and cup-like) shapes whose fluctuations, analogous to flickering of erythrocytes, and mutual transformations are studied in thermal equilibrium. Our simulations form a basis for quantitative analysis of recent experiments done on erythrocytes and artificial bilayer vesicles. They also predict effects that could be observed in experiments such as an "'unbinding" phenomenon, i.e., a separation of adhering cells induced by thermal fluctuations.
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