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  • Title: [Symptomatic hypocalcaemia on denosumab use].
    Author: Baptista Lopes V, Robbrecht D, van Thiel S, van Guldener C.
    Journal: Ned Tijdschr Geneeskd; 2013; 157(29):A6159. PubMed ID: 23859106.
    Abstract:
    BACKGROUND: Bone resorption inhibitors such as denosumab may induce symptomatic hypocalcaemia if a vitamin D deficiency is present. Amongst other causes, this type of deficiency may arise following bariatric surgery. CASE DESCRIPTION: We describe a 51-year-old woman who, a few years after undergoing bariatric surgery, developed symptomatic hypocalcaemia after she started taking denosumab. CONCLUSION: An adequate calcium and vitamin D status is a general condition before prescribing medication to treat osteoporosis. Therefore we recommend that before starting treatment with a bone resorption inhibitor that not only the calcium but also the vitamin D status should be determined, and if necessary, optimised.
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