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  • Title: Amphiphilic oligoethyleneimine-β-cyclodextrin "click" clusters for enhanced DNA delivery.
    Author: Martínez Á, Bienvenu C, Jiménez Blanco JL, Vierling P, Mellet CO, García Fernández JM, Di Giorgio C.
    Journal: J Org Chem; 2013 Aug 16; 78(16):8143-8. PubMed ID: 23859761.
    Abstract:
    Monodisperse amphiphilic oligoethyleneimine (OEI)-β-cyclodextrin (βCD) clusters have been prepared, and their potential as gene delivery systems has been evaluated in comparison with a nonamphiphilic congener. The general prototype incorporates tetraethyleneimine segments linked to the primary rim of βCD through either triazolyl or thioureidocysteaminyl connectors. Transfection efficiency data for the corresponding CD:pDNA nanocomplexes (CDplexes) in BNL-CL2 murine hepatocytes evidenced the strong beneficial effect of facial amphiphilicity.
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