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  • Title: Renal biopsy and family studies in 65 children with isolated hematuria.
    Author: Schröder CH, Bontemps CM, Assmann KJ, Schuurmans Stekhoven JH, Foidart JM, Monnens LA, Veerkamp JH.
    Journal: Acta Paediatr Scand; 1990; 79(6-7):630-6. PubMed ID: 2386054.
    Abstract:
    We have investigated 65 children with isolated hematuria persisting for at least a year. Renal biopsy specimens were studied by light microscopy, electron microscopy and immunofluorescence with antisera specific against basement membrane components. The majority of the biopsies (62/65) showed variable histologic abnormalities. Four categories could be distinguished on combined histological and clinical criteria: Alport syndrome (n = 8), benign hematuria (n = 33, familial in 23), IgA nephropathy (n = 16) and increase in mesangial cells and matrix (n = 5). On the basis of our results, we suggest that a renal biopsy can establish diagnosis and prognosis in those children with isolated hematuria where the family history is negative. If the family has adult male individuals with isolated hematuria, a biopsy can usually be avoided, since this family history effectively excludes Alport syndrome. The use of antisera against basement membrane components did not allow a differentiation between Alport syndrome and benign hematuria. Goodpasture serum immunofluorescence was variable in the former and normally present in the latter.
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