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  • Title: [Preformulation study of controlled release nitrofurantoin preparations. 2].
    Author: Marton S, Nguyen Thi Minh Tam, Antal I, Rácz I.
    Journal: Acta Pharm Hung; 1990 May; 60(2-3):57-67. PubMed ID: 2386073.
    Abstract:
    In their previous publications the authors rendered account of preparation and stability test of products containing controlled release nitrofurantoin in circumstances of preparing and storing. Following previous publications in vitro active principle release of developed product has been investigated by rotating basket method and by applying Sartorius Dissolution tester. Absorptions of active principle and coated pharmacon have been determined by means of Sartorius Membrane transport tester. On basis of results it can be ascertained that compressed and capsuled products coated with Eudragit L 100-55 has proved to be the most suitable concerning release of active principle as well as in vitro absorption. Taking into account probability values of absorption, active principle release and absorption of product have been properly controlled and so optimal bioavailability of the preparation can be expected.
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