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  • Title: Combining NHC-Cu and Brønsted base catalysis: enantioselective allylic substitution/conjugate additions with alkynylaluminum reagents and stereospecific isomerization of the products to trisubstituted allenes.
    Author: Dabrowski JA, Haeffner F, Hoveyda AH.
    Journal: Angew Chem Int Ed Engl; 2013 Jul 22; 52(30):7694-9. PubMed ID: 23864395.
    Abstract:
    All-catalytic route to trisubstituted allenes: The first examples of catalytic enantioselective allylic substitution reactions that involve alkyne-based nucleophiles and lead to products having tertiary stereogenic centers are followed by an exceptionally stereospecific amine-catalyzed isomerization to trisubstituted allenes (see picture; NHC = N-heterocyclic carbene).
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