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  • Title: The substrate for cholesterol 7alpha-hydroxylase.
    Author: Balasubramaniam S, Mitropoulos KA, Myant NB.
    Journal: Biochim Biophys Acta; 1975 Jul 22; 398(1):172-7. PubMed ID: 238645.
    Abstract:
    The rates of incorporation of (14C) cholesterol into cholesteryl esters and 5-cholestene-3beta,7alpha-diol (7alpha-hydroxycholesterol) by rat liver microsomes, measured under conditions in which esterification and 7alpha-hydroxylation are varied independently, indicated that cholesterol is the substrate for cholesterol 7alpha-hydroxylase. The specific activities of cholesteryl esters and 7alpha-hydroxycholeste ol in incubations of microsomes labelled with (14C)cholesterol in vitro or in vivo suggest that 7alpha-hydroxycholesterol and esterified cholesterol are not derived from the same pool of free cholesterol.
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