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  • Title: [Study of the trajectory of erythrocyte movement in microvessels using a method of automatic image analysis].
    Author: Lominadze DG, Shinkarenko VS, Mamisashvili VA.
    Journal: Biull Eksp Biol Med; 1990 Apr; 109(4):343-4. PubMed ID: 2386823.
    Abstract:
    Many physiological and pathological processes in the circulation are related to changes of blood rheological properties. Since blood represents a specific suspension of cells in plasma the mentioned changes are to a great degree dependent on behavior and interaction of red blood cells (RBC). For investigation of blood flow structure in microvessels we developed an algorithm and worked out a program for automatic treatment of RBC movement on the basis of automatic image analysis system "Leitz-TAS" (Ernst Leitz, FRG). The program was based on computation of coordinates of blood cell centers. Further we calculated the following values: the vector of displacements (S), its projection on both axes (dx, dy), their relationship (dy/dx), the relationship of RBC radial coordinate to vessel radius (y/R), and the velocity of RBC movements (V). Proceeding from these data we obtained such parameters, as e.g., the velocity profile, the radial displacements of red cells, etc. by which we could judge on the blood flow regime, the flow structure and changes of blood rheological properties.
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